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Both are frequently associated with "overlap disorders" or "shadow syndromes," as I like to call them. The most common "shadow syndromes" are irritable bowel syndrome, irritable bladder, temporomandibular dysfunction, and mitral valve prolapse. Others include premenstrual syndrome, primary dysmenorrhea, migraine, restless legs or periodic leg movements, Myofascial Pain Syndrome MPS , chemical sensitivities, autonomic dysfunction Neurally Mediated Hypotension and Postural Orthostatic Tachycardia Syndrome , Gulf War Syndrome, and possibly hyperextensibility, acne rosacea, Raynaud's phenomenon, sicca complex dry eyes and mouth and vasomotor rhinitis constant runny nose and congestion.
Note that the shadow syndromes occur predominantly in females, are defined clinically rather than by physical or laboratory findings, and many are associated with either pain or fatigue. It is likely that these disorders occur concurrently because they share a common biophysiological thread. The symptoms are similar for both syndromes, including debilitating fatigue, post-exertional malaise, feverishness, sore throat, headache, joint aches, a feeling of generalized weakness, subjective swelling, non-radicular paresthesias numbness or tingling that does not follow typical nerve patterns , memory loss, forgetfulness, confusion, irritability, and depressed mood.
There are some subtle differences, however. See Table 1 at end of article. Historically, CFS is frequently triggered by a flulike or infectious illness, but sometimes occurs after trauma or surgery. FM, on the other hand, is frequently triggered by trauma, less often by an infectious process. While there is a preponderance of women in both disorders, women are more likely to have FM than CFS The median age for both disorders is about 40 years, although all age groups are vulnerable, including children and seniors.
Familial aggregations and overlapping HLA haplotypes are described for both disorders. Physiologically, both disorders have in common reduced midbrain and cortical blood flow; autonomic dysfunction such as symptomatic orthostatic tachycardia and neurally mediated hypotension; suppression of the hypothalamic pituitary axis; disturbed Stage 4 sleep; reduced serum or CSF serotonin levels; and suppression of growth hormone, somatomedin C, or IGF1.
Similarities are summarized in Table 2. These differences may reflect why pain is a key symptom in FM, and viral symptoms predominate in CFS. In such instances, treatment is generally limited to supportive care and symptomatic therapy. You must be logged in to post a review. Telephone Helpline The ME Association telephone helpline — ME Connect — is available every day of the year, during the hours of 10amnoon, 2pm-4pm and 7pm-9pm.
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