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Show more related content. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. Extended-release niacin or ezetimibe and carotid intima-media thickness. A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events. Ann Intern Med. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
Effects of extended-release niacin with laropiprant in high-risk patients. Safety considerations with niacin therapy. Am J Cardiol. Mol Vis. Viljoen A, Wierzbicki AS. Safety and efficacy of laropiprant and extended-release niacin combination in the management of mixed dyslipidemias and primary hypercholesterolemia. Drug Health Patient Saf. Niacin in cardiovascular disease: recent preclinical and clinical developments.
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Cleve Clin J Med. Blomgarden Z, Handelsman Y. J Diabetes. Niacin for reduction of cardiovascular risk. Kones R. Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes.
Vasc Health Risk Manag. A prostaglandin J2 metabolite binds peroxisome proliferator activated receptor gamma and promotes adipocyte differentiation. Differential tissue and ligand-dependent signaling of GPRA receptor: implications for anti-atherosclerotic therapeutic potential. Cell Signal. Prostaglandins as modulators of imunity.
Trends Immunol. Harizi H. The immunobiology of prostanoid receptor signaling in connecting innate and adaptive immunity. Biomed Res Int. J Clin Pharm Ther. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline.
Washington, D. Shils ME, Shike M, editors. It may be that niacin, when taken with a statin, provides no additional bang for the buck. The significant decrease in heart attacks and strokes seen with statin therapy may overwhelm any potential benefit of niacin.
Further, as the study showed, the benefit of niacin may take up to 15 years to show benefit; the trials of statin-plus-niacin were only for years. My feeling is that niacin does have beneficial effects on cholesterol and on reducing atherosclerosis, or hardening of the arteries.
If you cannot tolerate a statin, niacin is a good option. This sometimes-severe condition is the most common reason people stop taking niacin. Facial flushing can be ameliorated by taking a slow release formulation of niacin or adding aspirin to niacin. Robert Ashley , Healthy Living , heart attacks , Heart Health , niacin , research , simvastatin , statins , strokes , vitamin B3 , Wellness.
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